Chemical Property of Tozadenant
Chemical Property:
- PKA:14.95±0.20(Predicted)
- PSA：115.40000
- Density:1.375 g/cm3
- LogP:2.59610
- Solubility.:insoluble in EtOH; insoluble in H2O; ≥20.35 mg/mL in DMSO
- XLogP3:1.7
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:3
- Exact Mass:406.16747650
- Heavy Atom Count:28
- Complexity:554
- Purity/Quality:
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99%, *data from raw suppliers
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1(CCN(CC1)C(=O)NC2=NC3=C(C=CC(=C3S2)N4CCOCC4)OC)O
- Recent ClinicalTrials:An fMRI Study of SYN115 in Cocaine Dependent Subjects
- Recent EU Clinical Trials:A Multicenter, Open-Label Study to Evaluate the Safety and Tolerability of Tozadenant as Adjunctive Therapy in Levodopa-Treated Patients with Parkinson’s Disease Experiencing End of Dose “Wearing-Off”
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Description
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively). It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson''s disease induced by 6-OHDA when administered at a dose of 30 mg/kg. Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson''s disease.
