1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

Base Information

Chemical Name:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid
CAS No.:1192829-38-1
Molecular Formula:C₂₅H₂₃ClN₄O₄
Molecular Weight:478.935
Hs Code.:

Synonyms:1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

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Chemical Property of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

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Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

There total 8 articles about 1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59378-87-9,68464-02-8,72580-53-1,72580-54-2
pyrrolidine-3-carboxylic acid

: 1192829-65-4
1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

: 1192829-38-1
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

Guidance literature:: pyrrolidine-3-carboxylic acid; With sodium hydride; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline; In dimethyl sulfoxide; at 120 ℃; for 3h; Inert atmosphere;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1192829-38-1
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidification

3.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

5.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

6.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C

6.2: 3 h / 120 °C / Inert atmosphere

With water; sodium hydride; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1192829-38-1
1-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1-isoquinolinyl]-3-pyrrolidinecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

3.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

4.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 3 h / 120 °C / Inert atmosphere

With sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trichlorophosphate; In dichloromethane; dimethyl sulfoxide;