N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Base Information

Chemical Name:N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide
CAS No.:1352416-75-1
Molecular Formula:C₁₈H₁₇F₄N₅O₃
Molecular Weight:427.358
Hs Code.:

Synonyms:N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

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Chemical Property of N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

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Technology Process of N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

There total 5 articles about N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1352420-58-6
C₁₇H₂₁F₄N₃O₃

: 40155-42-8
5-methoxy-pyrazine-2-carboxylic acid

: 1352416-75-1
N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: C₁₇H₂₁F₄N₃O₃; 5-methoxy-pyrazine-2-carboxylic acid; With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 ℃; for 20h;

With trifluoroacetic acid; In dichloromethane;

Reference yield: 65.0%

: (5R,6R)-5-(5-amino-2-fluorophenyl)-5-methyl-6-(trifluoromethyl)-5,6-dihydro-2H-1,4-oxazin-3-amine

: 40155-42-8
5-methoxy-pyrazine-2-carboxylic acid

: 1352416-75-1
N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: With 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol; at 0 ℃; for 6h;

Reference yield:

: 1352419-89-6
(5R)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-6-(trifluoromethyl)-morpholine-3-thione

: 1352416-75-1
N-{3-[(2R,3R)-5-amino-3-methyl-2-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-4-fluorophenyl}-5-methoxypyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: ammonia / methanol / 24 h / 80 °C

2: sodium azide; copper(l) iodide; N,N`-dimethylethylenediamine; sodium carbonate / dimethyl sulfoxide / 1 h / 110 °C

3: 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / methanol / 6 h / 0 °C

With copper(l) iodide; sodium azide; ammonia; sodium carbonate; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; N,N`-dimethylethylenediamine; In methanol; dimethyl sulfoxide;