5-METHOXYPYRAZINE-2-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
• CAS No.: 40155-42-8
• Molecular Formula: C6H6 N2 O3
• Molecular Weight: 154.125
• Hs Code.: 2933990090
• Mol file: 40155-42-8.mol

Synonyms:Pyrazinecarboxylicacid, 5-methoxy- (9CI);5-Methoxypyrazine-2-carboxylic acid;

Chemical Property of 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 197.5-199.5℃
• Boiling Point: 296.8 °C at 760 mmHg
• PKA: 3.18±0.10(Predicted)
• Flash Point: 133.3 °C
• PSA: 72.31000
• Density: 1.371 g/cm3
• LogP: 0.18340
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxypyrazine-2-carboxylic Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID

There total 6 articles about 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

sodium methylate (124-41-4) + 5-chloropyrazinoic acid (36070-80-1) → 5-methoxy-pyrazine-2-carboxylic acid (40155-42-8)

Guidance literature:

5-chloropyrazinoic acid; With sulfuric acid; In methanol; at 65 ℃; for 4h;

sodium methylate; In methanol; at 20 ℃; for 0.5h;

With sodium hydroxide; In methanol; water; at 40 ℃; for 1h;

Reference yield: 53.0%

→ 5-(3,3,3-trifluoropropoxy)pyrazine-2-carboxylic acid (1072855-47-0) + 5-methoxy-pyrazine-2-carboxylic acid (40155-42-8)

Guidance literature:

Reference yield:

2-bromo-5-methoxypyrazine (143250-10-6) + carbon monoxide (201230-82-2) → 5-methoxy-pyrazine-2-carboxylic acid (40155-42-8)

Guidance literature:

With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); triethylamine; In water; tert-butyl alcohol; at 60 ℃; for 48h; under 7500.75 - 11251.1 Torr; Autoclave; Inert atmosphere;

upstream raw materials:

5-chloropyrazinoic acid

methanol

2-bromo-5-methoxypyrazine

carbon monoxide

Downstream raw materials:

1-(5-methoxypyrazin-2-yl)ethanone

N-(3-((4S,6S)-2-benzamido-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide

C₁₈H₁₉FN₆O₅S

(R)-5-methoxy-pyrazine-2-carboxylic acid [3-(1-amino-7-fluoro-3-methyl-3,4-dihydro-pyrrolo[1,2-a]pyrazin-3-yl)-4-fluoro-phenyl]-amide

Refernces

• 1、 -. "FUSED AMINODIHYDROTHIAZINE DERIVATIVES". Page/Page column. . Retrieved 2014/07/08.
• 2、 -. "FUSED AMINODIHYDROTHIAZINE DERIVATIVES". Page/Page column 86-87. . Retrieved 2012/08/07.