40155-42-8

Basic information

• Product Name: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
• Synonyms: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID;2-Carboxy-5-methoxypyrazine, 2-Carboxy-5-methoxy-1,4-diazine;5-Methoxy-pyrazinecarboxylic acid;2-Pyrazinecarboxylicacid, 5-Methoxy-;5-Methoxypyrazine-2-carboxylic;Pyrazinecarboxylic acid, 5-methoxy-
• CAS NO: 40155-42-8
• Molecular Formula: C₆H₆N₂O₃
• Molecular Weight: 154.12
• Mol File: 40155-42-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 197.5-199.5℃
• Boiling Point: 296.8 °C at 760 mmHg
• Flash Point: 133.3 °C
• Appearance: /Solid
• Density: 1.371 g/cm3
• Storage Temp.: 2-8°C
• PKA: 3.18±0.10(Predicted)
• CAS DataBase Reference: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(40155-42-8)
• EPA Substance Registry System: 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID(40155-42-8)

Safety Data

• Hazardous Substances Data: 40155-42-8(Hazardous Substances Data)

Usage

General Description

5-Methoxypyrazine-2-carboxylic acid is a chemical compound that belongs to the pyrazine carboxylic acid family. It is a derivative of pyrazine and is also known as 5-Methoxypyrazine-2-carboxylic acid. 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID is a white to off-white powder that is sparingly soluble in water. It is commonly used as a flavor or fragrance ingredient due to its earthy, nutty, and green aroma. It is also used in the production of pharmaceuticals and agrochemicals. 5-Methoxypyrazine-2-carboxylic acid has been studied for its potential medicinal properties and has shown to have antioxidant and anti-inflammatory effects.

Upstream product

• 34604-60-9 5-hydroxypyrazinoic acid 
• 124-41-4 sodium methylate 
• 36070-80-1 5-chloropyrazinoic acid 
• 67-56-1 methanol 
• 143250-10-6 2-bromo-5-methoxypyrazine 
• 201230-82-2 carbon monoxide 

Downstream Products

• 1221447-97-7 C₂₈H₃₆N₆O₇ 
• 1432512-08-7 C₁₇H₁₆F₃N₅O₃ 
• 320592-61-8 1-(5-methoxypyrazin-2-yl)ethanone 
• 72788-88-6 (5-methoxypyrazin-2-yl)methanol 
• 32205-72-4 5-methoxypyrazine-2-carbaldehyde 
• 1383742-02-6 C₂₀H₁₇FN₈O₂ 
• 1383741-32-9 (R)-5-methoxy-pyrazine-2-carboxylic acid [3-(8-amino-6-methyl-5,6-dihydro-imidazo[1,2-a]pyrazin-6-yl)-4-fluoro-phenyl]-amide 
• 1391001-78-7 N-(3-((4aS,5S,7aS)-2-amino-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide 
• 1391001-96-9 tert-butyl ((4aS,5S,7aS)-5-(difluoromethyl)-7a-(2-fluoro-5-(5-methoxypyrazine-2-carboxamido)phenyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 
• 1391001-76-5 N-(3-((4aS,5S,7aS)-2-amino-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4,5-difluorophenyl)-5-methoxypyrazine-2-carboxamide 
• 1391001-86-7 tert-butyl ((4aS,5S,7aS)-7a-(2,3-difluoro-5-(5-methoxypyrazine-2-carboxamido)phenyl)-5-(difluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 
• 1388651-33-9 N-(3-((4aS,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4,5-difluorophenyl)-5-methoxypyrazine-2-carboxamide 
• 1391001-77-6 N-(3-((4aS,5S,7aS)-2-amino-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-methoxypyrazine-2-carboxamide 
• 1391001-95-8 tert-butyl ((4aS,5S,7aS)-7a-(2-fluoro-5-(5-methoxypyrazine-2-carboxamido)phenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)carbamate 

Relevant articles and documents

SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. Such diseases include, without limitation, neurological dysfunction such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and seizure disorders; emotional disorders; depression; bipolar disorder; obsessive-compulsive disorder; and other anxiety disorders.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; R is monofluoromethyl or difluoromethyl; and pharmaceutically acceptable salts thereof; which compound has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer-type dementia.

FUSED AMINODIHYDROTHIAZINE DERIVATIVES USEFUL AS BACE INHIBITORS

The present invention relates to a fused aminodihydrothiazine derivative of formula (I): wherein X is hydrogen or fluorine; A is CH or N; Y is methyl, ethyl, monofluoromethyl, difluoromethyl, trifluoromethyl, difluoroethyl, methoxy, ethoxy, methoxymethyl or -C≡N; and pharmaceutically acceptable salts thereof; which compound has an Αβ production inhibitory effect or a BACEl inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Αβ and typified by Alzheimer-type dementia.