bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Base Information

Chemical Name:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate
CAS No.:1622914-00-4
Molecular Formula:C₆₂H₇₄Cl₂F₂N₈O₁₀
Molecular Weight:1200.22
Hs Code.:

bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Synonyms:bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Suppliers and Price of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

There total 3 articles about bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1622913-96-5
4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl pent-4-ynoate

: 182760-73-2,82055-94-5
1,14-diazido-3,6,9,12-tetraoxatetradecane

: 1622914-00-4
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: With tetrakis(actonitrile)copper(I) hexafluorophosphate; In methanol; dichloromethane; at 40 ℃; for 4h;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 6089-09-4
4-pentynoic acid

: 1622914-00-4
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride / dichloromethane / 24 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

3: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane; methanol / 4 h / 40 °C

With oxalyl dichloride; tetrakis(actonitrile)copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079

Reference yield:

: 55183-44-3
4-pentynoic chloride

: 1622914-00-4
bis{4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl} 3,3’-[3,6,9,12-tetraoxatetradecane-1,14-diylbis(1H-1,2,3-triazole-1,4-diyl)]dipropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 19 h / 20 °C

2: tetrakis(actonitrile)copper(I) hexafluorophosphate / dichloromethane; methanol / 4 h / 40 °C

With tetrakis(actonitrile)copper(I) hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.06.079