4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester

Base Information

• Chemical Name: 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester
• CAS No.: 150272-18-7
• Molecular Formula: C₁₂H₁₅N₃O₈
• Molecular Weight: 329.266
• Mol file: 150272-18-7.mol

Synonyms:4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester

Chemical Property of 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester

There total 1 articles about 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 4-chloro-3,5-dinitrobenzoate (2552-45-6) + 2,2'-iminobis[ethanol] (111-42-2) → 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester (150272-18-7)

Guidance literature:

In 1,4-dioxane; at 50 ℃; for 5h;

DOI:10.1021/jm960057p

Reference yield:

methanesulfonyl chloride (124-63-0) + 4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester (150272-18-7) → 4-[Bis-(2-methanesulfonyloxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1021/jm960057p

Reference yield:

4-[Bis-(2-hydroxy-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester (150272-18-7) → 4-[Bis-(2-chloro-ethyl)-amino]-3,5-dinitro-benzoyl chloride (177035-50-6)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: LiCl / dimethylformamide / 0.08 h / 120 °C

3: 100 percent / 3N aq. KOH / dioxane / 3 h / 20 °C

4: DMF, SOCl₂ / 1,2-dichloro-ethane / 5 h / Heating

With potassium hydroxide; thionyl chloride; triethylamine; N,N-dimethyl-formamide; lithium chloride; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1021/jm960057p

upstream raw materials:

methyl 4-chloro-3,5-dinitrobenzoate

2,2'-iminobis[ethanol]

Downstream raw materials:

4-[Bis-(2-chloro-ethyl)-amino]-3,5-dinitro-benzoyl chloride

4-[Bis-(2-chloro-ethyl)-amino]-3,5-dinitro-benzoic acid

4-[Bis-(2-chloro-ethyl)-amino]-3,5-dinitro-benzoic acid methyl ester