all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol

Base Information

• Chemical Name: all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol
• CAS No.: 738616-39-2
• Molecular Formula: C₂₉H₃₄O₈
• Molecular Weight: 510.584
• Mol file: 738616-39-2.mol

Synonyms:all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol

Chemical Property of all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol

There total 12 articles about all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione (738616-33-6) → all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol (738616-39-2)

Guidance literature:

With diisobutylaluminium hydride; In toluene; at 20 ℃; for 24h;

DOI:10.1002/ejoc.200300782

Reference yield:

Veratric acid (93-07-2) → all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol (738616-39-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 77 percent / polyphosphoric acid / 0.5 h / 80 °C

2: 92 percent / pyridine; hydrogen / Pd/C / methanol / 168 h / 20 °C / 4500.45 Torr

3: 81 percent / para-toluenesulfonic acid monohydrate / benzene; 1,2-dichloro-ethane / 2 h / Heating

4: 75 percent / KF/Celite 545 / acetonitrile / 3 h / Heating

5: 82 percent / DIBAL-H / toluene / 24 h / 20 °C

With pyridine; potassium fluoride; PPA; Celite; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane; toluene; acetonitrile; benzene;

DOI:10.1002/ejoc.200300782

Reference yield:

bis(3,4-dimethoxyphenyl)methanone (4131-03-7) → all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol (738616-39-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / pyridine; hydrogen / Pd/C / methanol / 168 h / 20 °C / 4500.45 Torr

2: 81 percent / para-toluenesulfonic acid monohydrate / benzene; 1,2-dichloro-ethane / 2 h / Heating

3: 75 percent / KF/Celite 545 / acetonitrile / 3 h / Heating

4: 82 percent / DIBAL-H / toluene / 24 h / 20 °C

With pyridine; potassium fluoride; Celite; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane; toluene; acetonitrile; benzene;

DOI:10.1002/ejoc.200300782

upstream raw materials:

2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

5,6-dimethoxy-1-indanone

1,2-dimethoxybenzene

5,6-dimethoxyphthalide