2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

Base Information

• Chemical Name: 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione
• CAS No.: 738616-33-6
• Molecular Formula: C₂₉H₃₀O₈
• Molecular Weight: 506.552
• Mol file: 738616-33-6.mol

Synonyms:2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

Chemical Property of 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

There total 13 articles about 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3,3',4,4'-tetramethoxybenzhydrole (74084-26-7) + 5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione (738616-34-7) → 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione (738616-33-6)

Guidance literature:

With toluene-4-sulfonic acid; In 1,2-dichloro-ethane; toluene; at 120 ℃; for 3h; Inert atmosphere;

DOI:10.1002/anie.201808461

Reference yield: 75.0%

methyl iodide (74-88-4) + 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-1H-indene-1,3(2H)-dione (738616-29-0) → 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione (738616-33-6)

Guidance literature:

With potassium fluoride; Celite; In acetonitrile; for 3h; Heating;

DOI:10.1002/ejoc.200300782

Reference yield:

1,2-dimethoxybenzene (91-16-7) → 2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione (738616-33-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 77 percent / polyphosphoric acid / 0.5 h / 80 °C

2: 92 percent / pyridine; hydrogen / Pd/C / methanol / 168 h / 20 °C / 4500.45 Torr

3: 81 percent / para-toluenesulfonic acid monohydrate / benzene; 1,2-dichloro-ethane / 2 h / Heating

4: 75 percent / KF/Celite 545 / acetonitrile / 3 h / Heating

With pyridine; potassium fluoride; PPA; Celite; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; 1,2-dichloro-ethane; acetonitrile; benzene;

DOI:10.1002/ejoc.200300782

upstream raw materials:

3,3',4,4'-tetramethoxybenzhydrole

5,6-dimethoxy-2-methyl-1H-indene-1,3(2H)-dione

methyl iodide

2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-1H-indene-1,3(2H)-dione

Downstream raw materials:

all-cis-2-[bis(3,4-dimethoxyphenyl)methyl]-5,6-dimethoxy-2-methyl-1,3-indanediol