N-benzhydryl-2-chloroacetamide

Base Information

• Chemical Name: N-benzhydryl-2-chloroacetamide
• CAS No.: 10254-07-6
• Molecular Formula: C15H14 Cl N O
• Molecular Weight: 259.735
• Hs Code.: 2924299090
• European Community (EC) Number: 665-142-3
• DSSTox Substance ID: DTXSID30368044
• Nikkaji Number: J1.267.569K
• Wikidata: Q82154325
• Mol file: 10254-07-6.mol

Synonyms:N-benzhydryl-2-chloroacetamide;2-chloro-N-(diphenylmethyl)acetamide;10254-07-6;N-Benzhydryl-2-chloro-acetamide;SCHEMBL4665022;DTXSID30368044;YNIDNLNUYCFFTA-UHFFFAOYSA-N;MFCD01000034;STL382146;AKOS000369816;1-chloroacetylamino-1,1-diphenylmethane;LS-08882;CS-0116879;EN300-01650;Z56755219

Chemical Property of N-benzhydryl-2-chloroacetamide

Chemical Property:

• PSA: 29.10000
• LogP: 3.52190
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 259.0763918
• Heavy Atom Count: 18
• Complexity: 239

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-N-(diphenylmethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)NC(=O)CCl

Technology Process of N-benzhydryl-2-chloroacetamide

There total 7 articles about N-benzhydryl-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

chloroacetyl chloride (79-04-9) + Benzhydrylamine (91-00-9) → N-benzhydryl-2-chloroacetamide (10254-07-6)

Guidance literature:

With triethylamine; In dichloromethane; water;

Reference yield: 96.0%

1,1-Diphenylmethanol (91-01-0) + chloroacetonitrile (107-14-2) → N-benzhydryl-2-chloroacetamide (10254-07-6)

Guidance literature:

With silica-bonded N-propylsulphamic acid; In neat (no solvent); at 80 ℃; for 0.333333h; Green chemistry;

DOI:10.1007/s12039-012-0309-2

Reference yield: 95.0%

1,1-Diphenylmethanol (91-01-0) + Chloroacetamide (79-07-2) → N-benzhydryl-2-chloroacetamide (10254-07-6)

Guidance literature:

With aluminium(III) triflate; In nitromethane; at 70 ℃; for 1h; Microwave irradiation;

DOI:10.1002/adsc.201200536

upstream raw materials:

chloroacetyl chloride

Benzhydrylamine

chloroacetic acid

1,1-Diphenylmethanol

Downstream raw materials:

N-benzhydryl-2-morpholin-4-yl-acetamide

(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetic acid benzhydrylamide

BOC-Ala-OBg

BOC-Phe-OBg