1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Base Information

Chemical Name:1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride
CAS No.:1429757-68-5
Molecular Formula:C₂₃H₂₁Cl₂FN₄O₃*ClH
Molecular Weight:527.81
Hs Code.:

Synonyms:1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Suppliers and Price of 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Biosynth Carbosynth
Poziotinib hydrochloride
50 mg
$ 266.50

AK Scientific
1-[4-[4-(3,4-Dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one;hydrochloride
50mg
$ 409.00

AK Scientific
1-[4-[4-(3,4-Dichloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]prop-2-en-1-one;hydrochloride
10mg
$ 178.00

Total 20 raw suppliers

Chemical Property of 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Poziotinib hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Poziotinib Hydrochloride can be used to inhibit the growth of cancer cells.

Technology Process of 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

There total 6 articles about 1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1092364-38-9
1-(4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)prop-2-en-1-one

: 1429757-68-5
1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Guidance literature:: With hydrogenchloride; In water; dimethyl sulfoxide; at 20 ℃; for 6h; Solvent; Temperature;

Reference yield:

: 1429757-65-2
4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

: 1429757-68-5
1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 14 h / 70 °C

2: hydrogenchloride / acetone; water / 5.17 h

3: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 °C / Cooling with ice

4: hydrogenchloride / methanol; water / 24 h

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: tert-butyl 4-((4-((3,4-dichloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidine-1-carboxylate

: 1429757-68-5
1-[4-[4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy]-piperidin-1-yl]prop-2-en-1-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / acetone; water / 5.17 h

2: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 °C / Cooling with ice

3: hydrogenchloride / methanol; water / 24 h

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; methanol; water; acetone;