tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate
CAS No.:1403596-03-1
Molecular Formula:C₂₂H₃₁ClN₂O₄
Molecular Weight:422.952
Hs Code.:

Synonyms:tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1403595-31-2
tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate

: 106-95-6
allyl bromide

: 1403596-03-1
tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

Guidance literature:: tert-butyl 4-((5-chloro-3-(methoxycarbonyl)-2-methylphenyl)-amino)-piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

allyl bromide; In N,N-dimethyl-formamide; at 80 ℃; for 15h;

Reference yield:

: 154257-81-5
5-chloro-2-methyl-3-nitrobenzoic acid

: 1403596-03-1
tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: water; ammonium chloride; iron / ethanol / 1 h / 80 °C

3.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

4.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

4.2: 15 h / 80 °C

With water; sodium tris(acetoxy)borohydride; iron; sodium hydride; sodium carbonate; ammonium chloride; acetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 294190-18-4
methyl 3-amino-5-chloro-2-methylbenzoate

: 1403596-03-1
tert-butyl 4-(allyl(5-chloro-3-(methoxycarbonyl)-2-methylphenyl)amino)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 23 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 °C

2.2: 15 h / 80 °C

With sodium tris(acetoxy)borohydride; sodium hydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;