[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

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Chemical Name:[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine
CAS No.:182298-43-7
Molecular Formula:C₂₄H₃₄N₂O₆
Molecular Weight:446.544
Hs Code.:

Synonyms:[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

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Chemical Property of [(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

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Technology Process of [(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

There total 4 articles about [(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 100-39-0
benzyl bromide

: 182298-32-4
(R)-2-[(E)-Pyrrolidin-1-ylimino]-1-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-ethanol

: 182298-43-7
[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran;
DOI:10.1016/0040-4039(96)01226-9

Reference yield:

: 60144-26-5
formaldehyde N,N-tetramethylenehydrazone

: 182298-43-7
[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / CH₂Cl₂ / 20 °C

2: Bu₄NI; NaH / tetrahydrofuran / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo015711+

Reference yield:

: 4933-77-1
(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde

: 182298-43-7
[(R)-2-Benzyloxy-2-((3aR,5R,5aS,8aS,8bR)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-yl)-eth-(E)-ylidene]-pyrrolidin-1-yl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 68 percent / CH₂Cl₂ / 20 °C

2: Bu₄NI; NaH / tetrahydrofuran / 20 °C

With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo015711+