6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine

Base Information

• Chemical Name: 6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine
• CAS No.: 1448427-99-3
• Molecular Formula: C₁₀H₁₃N₅
• Molecular Weight: 203.247
• Mol file: 1448427-99-3.mol

Synonyms:6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine

Chemical Property of 6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine

Chemical Property:

• Boiling Point: 434.1±55.0 °C(Predicted)
• PKA: 3.80±0.29(Predicted)
• Density: 1.29±0.1 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

6-(4-Isopropyl-4h-1,2,4-triazol-3-yl)pyridin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine

There total 1 articles about 6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-chloropyridin-2-amine (45644-21-1) + 4-isopropyl-1,2,4-triazole (24463-56-7) → 6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine (1448427-99-3)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; caesium carbonate; In 1,4-dioxane; at 95 - 105 ℃;

Reference yield: 85.0%

6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine (1448427-99-3) + 5-cyano-2-methoxy-4-methylbenzoic acid → 5-cyano-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-methoxy-4-methylbenzamide

Guidance literature:

5-cyano-2-methoxy-4-methylbenzoic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In acetonitrile; at 20 ℃; for 1h;

6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine; In acetonitrile; at 20 ℃; for 0.5h;

DOI:10.1016/j.ejmech.2017.12.041

Reference yield: 85.0%

6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine (1448427-99-3) + C14H15FO4 → ethyl 2-(4-fluoro-5-((6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)carbamoyl)-2-methylphenyl)cyclopropane-1-carboxylate

Guidance literature:

C₁₄H₁₅FO₄; With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 20 ℃; for 1h;

6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-amine; With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃;

upstream raw materials:

6-chloropyridin-2-amine

4-isopropyl-1,2,4-triazole

Downstream raw materials:

5-(4-cyclopropyl-1H-imidazol-1-yl)-N-(6-(4-isopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-yl)-2-fluoro-4-methylbenzamide

5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide

Refernces