(2-FLUORO-PHENYL)-MORPHOLIN-4-YL-METHANONE

Base Information

• Chemical Name: (2-FLUORO-PHENYL)-MORPHOLIN-4-YL-METHANONE
• CAS No.: 1978-64-9
• Molecular Formula: C11H12 F N O2
• Molecular Weight: 209.22
• Hs Code.: 2934999090
• Mol file: 1978-64-9.mol

Synonyms:Morpholine,4-(2-fluorobenzoyl)- (9CI); Morpholine, 4-(o-fluorobenzoyl)- (6CI,8CI)

Chemical Property of (2-FLUORO-PHENYL)-MORPHOLIN-4-YL-METHANONE

Chemical Property:

• Melting Point: 75-77 °C
• Boiling Point: 350.3±37.0 °C(Predicted)
• PKA: -1.52±0.20(Predicted)
• PSA: 29.54000
• Density: 1.232±0.06 g/cm3(Predicted)
• LogP: 1.23600
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

N-(2-Fluorobenzoyl)morpholine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-FLUORO-PHENYL)-MORPHOLIN-4-YL-METHANONE

There total 8 articles about (2-FLUORO-PHENYL)-MORPHOLIN-4-YL-METHANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

morpholine (110-91-8,99108-56-2) + carbon monoxide (201230-82-2) + 1-Fluoro-2-iodobenzene (348-52-7) → (2-fluorophenyl)(morpholino)methanone (1978-64-9)

Guidance literature:

With dipotassium hydrogenphosphate; palladium; potassium iodide; In 1,4-dioxane; at 130 ℃; for 12h; under 3750.38 Torr; Autoclave; Green chemistry;

DOI:10.1039/c8gc00740c

Reference yield: 87.0%

4-morpholinocarbonyl chloride (15159-40-7) + 2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane (346656-39-1) → (2-fluorophenyl)(morpholino)methanone (1978-64-9)

Guidance literature:

With cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; at 80 ℃; for 16h;

DOI:10.1021/jo050459h

Reference yield: 56.0%

4-benzoylmorpholine (1468-28-6) → (2-fluorophenyl)(morpholino)methanone (1978-64-9)

Guidance literature:

With silver nitrate; N-fluorobis(benzenesulfon)imide; palladium dichloride; In 1,2-dichloro-ethane; at 90 ℃; for 24h; Sealed tube;

DOI:10.1021/acs.orglett.8b00793

upstream raw materials:

morpholine

2-Fluorobenzoyl chloride

4-morpholinocarbonyl chloride

2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane

Downstream raw materials:

C₁₁H₁₂FNOS

Refernces

• 1、 Samanta, Samya,Shah, Sk. Sheriff,Shee, Maniklal,Singh, Amit Kumar,Singh, N. D. Pradeep,Venkatesh, Yarra. "Organophotoredox-Mediated Amide Synthesis by Coupling Alcohol and Amine through Aerobic Oxidation of Alcohol". supporting information. . Retrieved 2020/03/05.