[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester
CAS No.:163776-50-9
Molecular Formula:C₁₆H₂₁NO₄
Molecular Weight:291.347
Hs Code.:

Synonyms:[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

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Chemical Property of [2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

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Technology Process of [2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

There total 5 articles about [2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 77-76-9
2,2-dimethoxy-propane

: 200122-22-1
methyl 2-(3,4-dihydroxy)pyrrolidinophenylacetate

: 163776-50-9
[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: With toluene-4-sulfonic acid; In acetone; for 48h;
DOI:10.1016/S0040-4020(97)01033-8

Reference yield:

: 3740-52-1
2-(2-nitrophenyl)acetic acid

: 163776-50-9
[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / conc. sulfuric acid / 4 h / Heating

2: hydrogen / Pd-C / methanol / 4 h / 2068.59 Torr

3: 398 mg / sodium bicarbonate / dimethylformamide / 20 °C

4: 90 percent / N-methylmorpholine N-oxide / osmium tetroxide / H₂O; acetone; 2-methyl-propan-2-ol / 20 °C

5: 94 percent / p-toluenesulfonic acid / acetone / 48 h

With sulfuric acid; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; palladium on activated charcoal; osmium(VIII) oxide; In methanol; water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 1: Esterification / 2: Hydrogenation / 3: Cyclization / 4: Oxidation / 5: Cyclization;
DOI:10.1016/S0040-4020(97)01033-8

Reference yield:

: 35613-44-6
2-aminophenylacetic acid methyl ester

: 163776-50-9
[2-((3aS,6aR)-2,2-Dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyrrol-5-yl)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 398 mg / sodium bicarbonate / dimethylformamide / 20 °C

2: 90 percent / N-methylmorpholine N-oxide / osmium tetroxide / H₂O; acetone; 2-methyl-propan-2-ol / 20 °C

3: 94 percent / p-toluenesulfonic acid / acetone / 48 h

With sodium hydrogencarbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; osmium(VIII) oxide; In water; N,N-dimethyl-formamide; acetone; tert-butyl alcohol; 1: Cyclization / 2: Oxidation / 3: Cyclization;
DOI:10.1016/S0040-4020(97)01033-8