3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Base Information

Chemical Name:3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile
CAS No.:1197342-26-9
Molecular Formula:C₁₈H₁₄BrN₃O
Molecular Weight:368.233
Hs Code.:

Synonyms:3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

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Chemical Property of 3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

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Technology Process of 3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

There total 4 articles about 3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 1197342-25-8
[3-(3-cyanophenyl)-3-oxopropyl]trimethylammonium iodide

: 1197342-26-9
3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: [3-(3-cyanophenyl)-3-oxopropyl]trimethylammonium iodide; With hydrazine hydrate; at 50 ℃; for 1h; Inert atmosphere;

3-Bromophenylacetic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 3-(4,5-dihydro-1H-pyrazol-3-yl)benzonitrile

: 98288-51-8
2-(3-bromophenyl)acetyl chloride

: 1197342-26-9
3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 5h; Inert atmosphere;

Reference yield:

: 6136-68-1
3-acethylbenzonitrile

: 1197342-26-9
3-{1-[2-(3-bromophenyl)acetyl]-4,5-dihydro-1H-pyrazol-3-yl}benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 18 h / 80 °C

1.2: pH 9

2.1: tetrahydrofuran / 48 h / 20 °C

3.1: hydrazine hydrate / 1 h / 50 °C / Inert atmosphere

3.2: 18 h / 20 °C

With hydrogenchloride; hydrazine hydrate; In tetrahydrofuran; ethanol; water;