2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate
• CAS No.: 253268-23-4
• Molecular Formula: C₈H₅Cl₂F₃O₄S
• Molecular Weight: 325.093
• Mol file: 253268-23-4.mol

Synonyms:2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate

Chemical Property of 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate

There total 1 articles about 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trifluoromethylsulfonic anhydride (358-23-6) + 2,4-dichloro-5-methoxyphenol (18113-13-8) → 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate (253268-23-4)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at -70 - 20 ℃; for 0.333333h;

DOI:10.1016/S0223-5234(99)00220-2

Reference yield: 36.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate (253268-23-4) → methyl 2,4-dichloro-5-methoxybenzoate (253268-24-5)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In N,N-dimethyl-formamide; at 70 ℃; for 5h; under 760 Torr;

DOI:10.1016/S0223-5234(99)00220-2

Reference yield:

2,4-dichloro-5-methoxyphenyl trifluoromethanesulfonate (253268-23-4) → 4,6-dichloro-3-hydroxy-2-nitrobenzoic acid (253268-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 36 percent / 1,3-bis(diphenylphosphino)propane; NEt₃ / Pd(OAc)2 / dimethylformamide / 5 h / 70 °C / 760 Torr

2: 66 percent / BBr₃ / CH₂Cl₂ / 4 h / -70 - 20 °C

3: 95 percent / 90 percent HNO₃ / nitromethane / 4 h / 45 °C

With 1,3-bis-(diphenylphosphino)propane; nitric acid; boron tribromide; triethylamine; palladium diacetate; In nitromethane; dichloromethane; N,N-dimethyl-formamide; 1: Carboxylation / 2: demethylation / 3: Nitration;

DOI:10.1016/S0223-5234(99)00220-2

upstream raw materials:

trifluoromethylsulfonic anhydride

2,4-dichloro-5-methoxyphenol

Downstream raw materials:

methyl 2,4-dichloro-5-methoxybenzoate

2,4-dichloro-5-hydroxybenzoic acid

4,6-dichloro-3-hydroxyanthranilic acid

4,6-dichloro-3-hydroxy-2-nitrobenzoic acid

Refernces