(S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

Base Information

Chemical Name:(S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate
CAS No.:1334324-78-5
Molecular Formula:C₂₂H₂₃NO₅
Molecular Weight:381.428
Hs Code.:

Synonyms:(S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

Suppliers and Price of (S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

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Technology Process of (S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

There total 2 articles about (S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 64286-85-7
N-(benzyloxycarbonyl)-L-phenylalanine allyl ester

: 78-94-4,25038-87-3
methyl vinyl ketone

: 1334324-78-5
(S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 45 ℃; for 4h; Inert atmosphere;
DOI:10.1021/ol202276h

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1334324-78-5
(S,E)-4-oxopent-2-en-1-yl 2-(((benzyloxy)carbonyl)amino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

2: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202276h