Technology Process of 3-phenyl-1-(pyridin-2-yl)prop-2-yn-1-yl pivalate
There total 4 articles about 3-phenyl-1-(pyridin-2-yl)prop-2-yn-1-yl pivalate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 20 ℃;
for 3h;
DOI:10.1021/ol0701971
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 20 °C
1.2: 100 percent / tetrahydrofuran / 1 h / 0 °C
2.1: 86 percent / triethylamine; 4-(dimethylamino)pyridine / CH2Cl2 / 3 h / 20 °C
With
dmap; ethylmagnesium bromide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0701971
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ethylmagnesium bromide / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 3 h / -78 - 20 °C / Inert atmosphere
2.1: dmap; triethylamine / dichloromethane / 0.08 h / 0 °C
2.2: 0.67 h / 0 °C
With
dmap; ethylmagnesium bromide; triethylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol302947r
