(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

Base Information

Chemical Name:(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide
CAS No.:1417179-46-4
Molecular Formula:C₂₇H₂₄F₂N₄O₅S₂
Molecular Weight:586.64
Hs Code.:

Synonyms:(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

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Chemical Property of (R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

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Technology Process of (R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

There total 4 articles about (R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1044597-03-6
(R)-6,8-difluorochroman-3-amine L-tartrate salt

: 1417179-45-3
N-benzyl-N-(4-hydroxy-3-oxobutyl)-2-nitrobenzenesulfonamide

: 333-20-0
potassium thioacyanate

: 1417179-46-4
(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

Guidance literature:: With acetic acid; at 100 ℃; for 3h;

Reference yield:

: 1694-92-4
2-Nitrobenzenesulfonyl chloride

: 1417179-46-4
(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 5 - 10 °C

2: potassium tert-butylate / ethyl acetate / 1 h / 20 - 25 °C

3: acetic acid / 3 h / 100 °C

With potassium tert-butylate; acetic acid; triethylamine; In dichloromethane; ethyl acetate;

Reference yield:

: 1417179-42-0
N-benzyl-2-nitro-N-(3-oxobutyl)benzenesulfonamide

: 1417179-46-4
(R)-N-benzyl-N-(2-(3-(6,8-difluorochroman-3-yl)-2-thioxo-2,3-dihydro-1H-imidazol-4-yl)ethyl)-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / methanol; water / 20.5 h / 20 °C / Reflux

2: potassium formate; formic acid; methanol / 2 h / Reflux

3: acetic acid / 3 h / 100 °C

With methanol; formic acid; bromine; potassium formate; acetic acid; In methanol; water;