1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

Base Information

Chemical Name:1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine
CAS No.:150013-61-9
Molecular Formula:C₂₄H₂₇N
Molecular Weight:329.485
Hs Code.:

Synonyms:1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

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Chemical Property of 1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

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Technology Process of 1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

There total 10 articles about 1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1336-21-6
ammonium hydroxide

: 100-58-3
phenylmagnesium bromide

: 150013-63-1
3-<(3,6-dihydro-4-phenyl-1(2H)-pyridinyl)methyl>cyclohexanone

: 150013-61-9,150013-70-0
1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

: 1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-2-cyclohexen-1-yl)methyl>pyridine

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; hydrogenchloride; diethyl ether;

Reference yield:

: 16205-98-4
3-oxo-cyclohexanecarboxylic acid

: 150013-61-9,150013-70-0
1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 1-hydroxybenzotriazole hydrate, DCC, Et₃N / CH₂Cl₂ / Ambient temperature

2: MeSO₃H / CH₂Cl₂ / 72 h / Ambient temperature

3: LiAlH₄, AlCl₃ / diethyl ether; tetrahydrofuran / 12 h / Ambient temperature

4: 2N aq. HCl / acetone / 6 h / Heating

5: tetrahydrofuran; diethyl ether / 3 h / 0 °C

6: CF₃COOH / 1,2-dichloro-ethane / 2 h

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; methanesulfonic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00047a010

Reference yield:

: 43064-12-6
1,2,3,6-tetrahydro-4-phenylpyridine hydrochloride

: 150013-61-9,150013-70-0
1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 1-hydroxybenzotriazole hydrate, DCC, Et₃N / CH₂Cl₂ / Ambient temperature

2: MeSO₃H / CH₂Cl₂ / 72 h / Ambient temperature

3: LiAlH₄, AlCl₃ / diethyl ether; tetrahydrofuran / 12 h / Ambient temperature

4: 2N aq. HCl / acetone / 6 h / Heating

5: tetrahydrofuran; diethyl ether / 3 h / 0 °C

6: CF₃COOH / 1,2-dichloro-ethane / 2 h

With hydrogenchloride; lithium aluminium tetrahydride; aluminium trichloride; methanesulfonic acid; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00047a010