di(4-tolyl)methylphosphine oxide

Base Information

• Chemical Name: di(4-tolyl)methylphosphine oxide
• CAS No.: 723-45-5
• Molecular Formula: C₁₅H₁₇OP
• Molecular Weight: 244.273
• Mol file: 723-45-5.mol

Synonyms:di(4-tolyl)methylphosphine oxide

Chemical Property of di(4-tolyl)methylphosphine oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of di(4-tolyl)methylphosphine oxide

There total 9 articles about di(4-tolyl)methylphosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di(p-tolyl)phosphine oxide (2409-61-2) + methyl iodide (74-88-4) → di(4-tolyl)methylphosphine oxide (723-45-5)

Guidance literature:

With potassium hydroxide; In water; dimethyl sulfoxide; at 60 ℃; for 1h;

DOI:10.1039/d1ob00086a

Reference yield: 44.0%

para-bromotoluene (106-38-7) + tetrakis(hydroxymethyl)phosphonium chloride (124-64-1) → di(4-tolyl)methylphosphine oxide (723-45-5) + tri(4-methylphenyl)phosphine oxide (797-70-6)

Guidance literature:

With 3 A molecular sieve; potassium carbonate; [(o-Tol)2PC₆H₄CH₂Pd(OAc)]2; In N,N-dimethyl acetamide; at 130 ℃; for 17h;

DOI:10.1080/00397910008087212

Reference yield:

bis(4-methylphenyl)phosphinic acid (1084-11-3) → di(4-tolyl)methylphosphine oxide (723-45-5)

Guidance literature:

With thionyl chloride; beim Behandeln anschliessend mit Methylmagnesiumhalogenid;

DOI:10.1021/ja01166a518

upstream raw materials:

bis(4-methylphenyl)phosphinic acid

methyl-tris(p-toluylphenyl)phosphonium iodide

methylphosphonic acid dichloroanhydride

para-methylphenylmagnesium bromide