(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

Base Information

Chemical Name:(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol
CAS No.:1062669-94-6
Molecular Formula:C₂₄H₃₂N₄O₄
Molecular Weight:440.542
Hs Code.:

Synonyms:(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

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Chemical Property of (S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

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Technology Process of (S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

There total 6 articles about (S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1062669-89-9
4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-1,2,4-oxadiazol-3-yl)-2-ethyl-6-methylphenol

: 60827-45-4
(S)-3-chloropropan-1,2-diol

: 1062669-94-6
(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

Guidance literature:: With sodium hydroxide; In water; isopropyl alcohol; at 60 ℃; for 15h;
DOI:10.1021/jm4014696

Reference yield:

: 75308-46-2
tert-butyl 2,6-dichloropyridine-4-carboxylate

: 1062669-94-6
(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 72 h / 100 °C / Sealed tube; Inert atmosphere

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; tetrahydrofuran / 16 h / 75 °C / Inert atmosphere

3.1: hydrogenchloride / water / 24 h / 80 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

4.2: 80 - 100 °C / Inert atmosphere

5.1: sodium hydroxide / water; isopropyl alcohol / 15 h / 60 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm4014696

Reference yield:

: 1365337-42-3
tert-butyl 2-chloro-6-(diethylamino)isonicotinate

: 1062669-94-6
(S)-3-(4-(5-(2-(diethylamino)-6-methylpyridin-4-yl)-[1,2,4]oxadiazol-3-yl)-2-ethyl-6-methylphenoxy)propane-1,2-diol

Guidance literature:: Multi-step reaction with 4 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; tetrahydrofuran / 16 h / 75 °C / Inert atmosphere

2.1: hydrogenchloride / water / 24 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 20 °C / Inert atmosphere

3.2: 80 - 100 °C / Inert atmosphere

4.1: sodium hydroxide / water; isopropyl alcohol / 15 h / 60 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; isopropyl alcohol;
DOI:10.1021/jm4014696