N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Name:N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
CAS No.:1394820-93-9
Molecular Formula:C₃₂H₃₂N₄O₆
Molecular Weight:568.629
Hs Code.:

Synonyms:N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Property of N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Technology Process of N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 8 articles about N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.3%

: 558-30-5
2-methyl-1,2-epoxypropane

: 1394821-14-7
N-(4-((7-hydroxy-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

: 1394820-93-9
N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide; at 60 ℃; for 12h;

Reference yield:

: 1835-11-6
4-benzyloxy-3-methoxyacetophenone

: 1394820-93-9
N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / dichloromethane / 1 h / 0 °C / pH 7 - 8

2.1: ammonium formate; iron / toluene; water / 103 °C

3.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C

3.2: 8 h

4.1: trichlorophosphate / toluene / 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / xylene / 12 h / Reflux

6.1: potassium formate / palladium 10% on activated carbon / water; methanol / Reflux

7.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 10 h / 60 °C

8.1: potassium carbonate / N,N-dimethyl-formamide; water / 12 h / 60 °C

With 1-hydroxy-7-aza-benzotriazole; sulfuric acid; nitric acid; ammonium formate; sodium methylate; potassium formate; iron; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; Dimethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; xylene;

Reference yield:

: 75665-73-5
1-(2-amino-4-(benzyloxy)-5-methoxyphenyl)ethanone

: 1394820-93-9
N-(4-((7-(2-hydroxy-2-methylpropoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium methylate / Dimethyl ether / 0.5 h / 20 °C

1.2: 8 h

2.1: trichlorophosphate / toluene / 2 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / xylene / 12 h / Reflux

4.1: potassium formate / palladium 10% on activated carbon / water; methanol / Reflux

5.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 10 h / 60 °C

6.1: potassium carbonate / N,N-dimethyl-formamide; water / 12 h / 60 °C

With 1-hydroxy-7-aza-benzotriazole; sodium methylate; potassium formate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; Dimethyl ether; water; N,N-dimethyl-formamide; toluene; xylene;