2,4-Pyrimidinediamine, N4,N4-dimethyl- (9CI)

Base Information

• Chemical Name: 2,4-Pyrimidinediamine, N4,N4-dimethyl- (9CI)
• CAS No.: 1005-26-1
• Molecular Formula: C6H10 N4
• Molecular Weight: 138.172
• Hs Code.: 2933599090
• Mol file: 1005-26-1.mol

Synonyms:Pyrimidine,2-amino-4-(dimethylamino)- (7CI,8CI); 2-Amino-4-(dimethylamino)pyrimidine;4-(Dimethylamino)-2-pyrimidinamine

Chemical Property of 2,4-Pyrimidinediamine, N4,N4-dimethyl- (9CI)

Chemical Property:

• PSA: 55.77000
• LogP: 0.05490

Purity/Quality:

98%,99%, ^*data from raw suppliers

N4,N4-Dimethylpyrimidine-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pyrimidinediamine, N4,N4-dimethyl- (9CI)

There total 3 articles about 2,4-Pyrimidinediamine, N4,N4-dimethyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-amino-4-chloropyrimidine (3993-78-0) + dimethyl amine (124-40-3) → N4,N4-dimethylpyrimidine-2,4-diamine (1005-26-1)

Guidance literature:

In water; at 100 ℃; Sealed tube;

Reference yield: 43.0%

2-amino-4-chloropyrimidine (3993-78-0) + N,N-dimethylammonium chloride (506-59-2) → N4,N4-dimethylpyrimidine-2,4-diamine (1005-26-1)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.7b00632

Reference yield: 43.0%

→ N4,N4-dimethylpyrimidine-2,4-diamine (1005-26-1)

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 2h; Inert atmosphere;

upstream raw materials:

2-amino-4-chloropyrimidine

dimethyl amine

N,N-dimethylammonium chloride

Refernces

• 1、 Chen, An,Narva, Suresh,Shi, Jia,Wu, Dong-Liang,Wu, Yan-Ling,Zhang, Wen,Zhao, Xiao-Yin. "Design, synthesis and biological evaluation of 2-methyl-(1,1′-biphenyl)-pyrimidine conjugates". . . Retrieved 2020.
• 2、 -. "SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS". Paragraph 0876; 0877. . Retrieved 2015/06/10.