2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

Base Information

Chemical Name:2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester
CAS No.:105780-09-4
Molecular Formula:C₁₆H₁₉NO₄
Molecular Weight:289.331
Hs Code.:

Synonyms:2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

There total 3 articles about 2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 105780-06-1
(3S,4S)-1-Benzyl-4-ethynyl-3-((R)-1-hydroxy-ethyl)-azetidin-2-one

: 105780-09-4
2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

: (Z)-2-[1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-but-2-enedioic acid dimethyl ester

Guidance literature:: With hydrogen iodide; palladium; at 65 ℃; for 16h; under 14710.2 Torr;
DOI:10.1016/S0040-4039(00)84472-X

Reference yield:

: 101911-11-9
N-<3-(trimethylsilyl)-2-propynylidene>benzylamine

: 105780-09-4
2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent

2: 1.) KOH, H₂O, 2.) (PyS)2-Ph₃P / 1.) THF, 2.) CH₃CN

3: 70 percent / HI / 10percent Pd / 16 h / 65 °C / 14710.2 Torr

With potassium hydroxide; water; hydrogen iodide; triphenylphosphine; palladium;
DOI:10.1016/S0040-4039(00)84472-X

Reference yield:

: 107544-36-5,108102-75-6
3-Benzylamino-2-((R)-1-hydroxy-ethyl)-5-trimethylsilanyl-pent-4-ynethioic acid S-phenyl ester

: 105780-09-4
2-[(2S,3S)-1-Benzyl-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-acrylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) KOH, H₂O, 2.) (PyS)2-Ph₃P / 1.) THF, 2.) CH₃CN

2: 70 percent / HI / 10percent Pd / 16 h / 65 °C / 14710.2 Torr

With potassium hydroxide; water; hydrogen iodide; triphenylphosphine; palladium;
DOI:10.1016/S0040-4039(00)84472-X