methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Base Information

Chemical Name:methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate
CAS No.:502481-65-4
Molecular Formula:C₃₄H₄₁ClN₄O₈
Molecular Weight:669.175
Hs Code.:

methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Synonyms:methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

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Chemical Property of methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

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Technology Process of methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

There total 11 articles about methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61161-83-9
5-(hydroxymethyl)-2-nitrophenol

: 502481-65-4
methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃ / dimethylformamide / 50 °C

2: Et₃N / CH₂Cl₂ / 0 °C

3: dimethylformamide / 20 °C

4: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

5: ethyl acetate / 20 °C

6: H₂ / 10 percent Pd/C contd. 50 percent water / ethyl acetate / 20 °C / atmospheric pressure

7: Et₃N / ethyl acetate / 0 - 20 °C

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; 10 percent Pd/C contd. 50 percent water; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 502481-65-4
methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 94 percent / (MeO)3B; BF₃*OEt₂; BH₃*pyridine / 1,2-dichloro-ethane / 4 h / 20 °C

2: K₂CO₃ / dimethylformamide / 50 °C

3: Et₃N / CH₂Cl₂ / 0 °C

4: dimethylformamide / 20 °C

5: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

6: ethyl acetate / 20 °C

7: H₂ / 10 percent Pd/C contd. 50 percent water / ethyl acetate / 20 °C / atmospheric pressure

8: Et₃N / ethyl acetate / 0 - 20 °C

With borane pyridine; Trimethyl borate; boron trifluoride diethyl etherate; hydrogen; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; 10 percent Pd/C contd. 50 percent water; In tetrahydrofuran; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l

Reference yield:

: 135206-87-0
(2R)-1-morpholin-4-yl-1-oxopropane-2-ol

: 502481-65-4
methyl (3S)-7-chloro-3-(2-((1S)-1-morpholinocarbonylethoxy)-4-tert-butoxycarbonylaminomethylphenyl)aminocarbonylmethyl-1,3,4,5-tetrahydrobenz[cd]indole-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / tetrahydrofuran / 0 - 50 °C

1.2: tetrahydrofuran / 0 - 5 °C

2.1: K₂CO₃ / dimethylformamide / 50 °C

3.1: Et₃N / CH₂Cl₂ / 0 °C

4.1: dimethylformamide / 20 °C

5.1: N₂H₄*H₂O; p-TsOH*H₂O / tetrahydrofuran / Heating

6.1: ethyl acetate / 20 °C

7.1: H₂ / 10 percent Pd/C contd. 50 percent water / ethyl acetate / 20 °C / atmospheric pressure

8.1: Et₃N / ethyl acetate / 0 - 20 °C

With hydrogen; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate; triethylamine; 10 percent Pd/C contd. 50 percent water; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020239l