61161-83-9

Usage

Uses

Used in Pharmaceutical Industry:
5-(hydroxymethyl)-2-nitrophenol is used as a precursor in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with potential therapeutic applications.
Used in Dye Industry:
In the dye industry, 5-(hydroxymethyl)-2-nitrophenol is utilized as a starting material for the production of dyes, taking advantage of its chemical properties to create a range of colorants for different applications.
Used in Antiseptic and Antimicrobial Agents:
5-(hydroxymethyl)-2-nitrophenol is used as an active ingredient in antiseptic and antimicrobial agents for its antibacterial and antifungal properties, helping to prevent infections and promote healing.
Used in Cancer Treatment Research:
5-(hydroxymethyl)-2-nitrophenol is studied for its potential use in cancer treatment, as it has shown the ability to inhibit the growth of tumor cells, offering a possible avenue for developing new therapeutic approaches against cancer.

Upstream product

• 121-43-7 Trimethyl borate 
• 619-14-7 3-hydroxy-4-nitro-benzoic acid 
• 109-63-7 trifluoroborane diethyl ether 
• 123-91-1 1,4-dioxane 
• 704-13-2 5-formyl-2-nitrophenol 
• 713-52-0 methyl 3-hydroxy-4-nitrobenzoate 
• 36852-58-1 3-Hydroxy-4-nitro-benzoylchlorid 

Downstream Products

• 704-13-2 5-formyl-2-nitrophenol 
• 42533-61-9 3-hydroxy-4-nitro benzyl chloride 
• 26386-82-3 5-(bromomethyl)-2-nitrophenol 
• 193957-49-2 5-[(E)-4-(4-Dimethylamino-phenyl)-but-1-en-3-ynyl]-2-nitro-phenol 
• 182913-52-6 Acetic acid 5-acetoxymethyl-2-nitro-phenyl ester 
• 502481-62-1 2-((S)-1-morpholinocarbonylethoxy)-4-hydroxymethylnitrobenzene 
• 295788-50-0 2-((R)-1-morpholinocarbonylethoxy)-4-hydroxymethylnitrobenzene 
• 188907-48-4 diethyl 3-hydroxy-4-nitrobenzylphosphonate 
• 133332-18-0 3-cyclopentoxy-4-nitrobenzyl alcohol 
• 114484-31-0 2-amino-5-(hydroxymethyl)phenol 
• 824933-92-8 5-Methoxymethyl 2-Nitro phenol 
• 929095-36-3 methyl 5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate 
• 929095-37-4 methyl 5-[(2-amino-5-{[(2,2-dimethylpropanoyl)oxy]methyl}phenyl)amino]-3-({(1R)-1-[2-(trifluoromethyl)phenyl]ethyl}oxy)thiophene-2-carboxylate 
• 929095-60-3 methyl 3-{[(1R)-1-(2-chlorophenyl)ethyl]oxy}-5-[(5-{[(2,2-dimethylpropanoyl)oxy]methyl}-2-nitrophenyl)amino]-2-thiophenecarboxylate 

Relevant academic research and scientific papers

SUBSTITUTED HYDROXYSTILBENE COMPOUNDS AND DERIVATIVES SYNTHESIS AND USES THEREOF

The present disclosure relates to substituted hydroxystilbene compounds and derivatives, specifically 2-substituted hydroxystilbene compounds and derivatives, the synthesis of such compounds and their use in therapy.

Conjugatable and Bioreduction Cleavable Linker for the 5′-Functionalization of Oligonucleotides

An efficient conjugatable and bioreduction cleavable linker was designed and synthesized for the 5′-terminal ends of oligonucleotides. A phosphoramidite reagent bearing this linker was successfully applied to solid phase synthesis and incorporated at the 5′-terminal ends of oligonucleotides. The controlled pore glass (CPG)-supported oligonucleotides were subsequently conjugated to a diverse range of functional molecules using a CuAAC reaction. The synthesized oligonucleotide conjugates were then cleaved using a nitroreductase/NADH bioreduction system to release the naked oligonucleotides.

BICYCLIC COMPOUND

Provided is a bicyclic compound having an acetyl-CoA carboxylase inhibitory action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has an acetyl-CoA carboxylase inhibitory action, is useful for the prophylaxis or treatment of cancer, inflammatory diseases and the like, and has superior efficacy.

Thermally robust Au99(SPh)42 nanoclusters for chemoselective hydrogenation of nitrobenzaldehyde derivatives in water

We report the synthesis and catalytic application of thermally robust gold nanoclusters formulated as Au99(SPh)42. The formula was determined by electrospray ionization and matrix-assisted laser desorption ionization mass spectrometry in conjunction with thermogravimetric analysis. The optical spectrum of Au99(SPh)42 nanoclusters shows absorption peaks at ～920 nm (1.35 eV), 730 nm (1.70 eV), 600 nm (2.07 eV), 490 nm (2.53 eV), and 400 nm (3.1 eV) in contrast to conventional gold nanoparticles, which exhibit a plasmon resonance band at 520 nm (for spherical particles). The ceria-supported Au99(SPh)42 nanoclusters were utilized as a catalyst for chemoselective hydrogenation of nitrobenzaldehyde to nitrobenzyl alcohol in water using H2 gas as the hydrogen source. The selective hydrogenation of the aldehyde group catalyzed by nanoclusters is a surprise because conventional nanogold catalysts instead give rise to the product resulting from reduction of the nitro group. The Au 99(SPh)42/CeO2 catalyst gives high catalytic activity for a range of nitrobenzaldehyde derivatives and also shows excellent recyclability due to its thermal robustness. We further tested the size-dependent catalytic performance of Au25(SPh)18 and Au36(SPh)24 nanoclusters, and on the basis of their crystal structures we propose a molecular adsorption site for nitrobenzaldehyde. The nanocluster material is expected to find wide application in catalytic reactions.

Diphenylpolyene-cholesterol conjugates as fluorescent probes for microheterogeneous media

Extrinsically conjugated fluorescent diphenylpolyene cholesterol derivatives are synthesized and spectroscopic investigations in homogeneous and aqueous micellar solutions are described. The emission of these cholesterol conjugates reveals characteristic

Benzimidazole Thiophene Compounds

The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Regioselective synthesis of benzimidazole thiophene inhibitors of polo-like kinase 1

A regioselective synthesis of novel 1-(2-thienyl)-benzimidazole inhibitors of polo-like kinase 1 is described. Amination of substituted 2-iodo or -bromo nitrobenzenes with a 2-aminothiophene derivative catalyzed by Pd2dba3 and XANTPH

BENZIMIDAZOLE THIOPHENE COMPOUNDS

The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES

The present invention provides a process for preparing benzimidazole thiophene compounds of formula I. Intermediates used in the process are also claimed.

BENZIMIDAZOLE THIOPHENE COMPOUNDS

The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.