methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

Base Information

Chemical Name:methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate
CAS No.:1394821-11-4
Molecular Formula:C₂₀H₁₇FN₂O₆
Molecular Weight:400.363
Hs Code.:

Synonyms:methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

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Chemical Property of methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

Chemical Property:

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Technology Process of methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

There total 6 articles about methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.5%

: 67-56-1
methanol

: 1394821-10-3
2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoic acid

: 1394821-11-4
methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 1484-26-0
3-(benzyloxy)aniline

: 1394821-11-4
methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 1 h / Reflux

2: 1,2-dichloro-benzene / 5 h / Reflux

3: trichlorophosphate / toluene / 1 h / 120 °C

4: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 115 °C

5: hydrogenchloride; water / 1,4-dioxane / 24 h / 100 °C

6: sodium hydroxide / 1 h / 20 °C

7: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-benzene; toluene;

Reference yield:

: 1394820-97-3
7-benzyloxy-4-(2-fluoro-4-nitrophenoxy)quinoline

: 1394821-11-4
methyl 2-((4-(2-fluoro-4-nitrophenoxy)quinolin-7-yl)oxy)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride; water / 1,4-dioxane / 24 h / 100 °C

2: sodium hydroxide / 1 h / 20 °C

3: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In 1,4-dioxane; dichloromethane;