N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Name:N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide
CAS No.:1394820-91-7
Molecular Formula:C₃₁H₂₉FN₄O₅
Molecular Weight:556.593
Hs Code.:

Synonyms:N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Chemical Property of N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

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Technology Process of N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

There total 10 articles about N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

: 1394821-13-6
2-((4-(4-amino-2-fluorophenoxy)quinolin-7-yl)oxy)-2-methylpropan-1-ol

: 83-10-3
antipyric acid

: 1394820-91-7
N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 4h; Reflux;

Reference yield:

: 1484-26-0
3-(benzyloxy)aniline

: 1394820-91-7
N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: ethanol / 1 h / Reflux

2: 1,2-dichloro-benzene / 5 h / Reflux

3: trichlorophosphate / toluene / 1 h / 120 °C

4: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 115 °C

5: hydrogenchloride; water / 1,4-dioxane / 24 h / 100 °C

6: sodium hydroxide / 1 h / 20 °C

7: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

8: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

9: potassium formate / 5%-palladium/activated carbon / water; tetrahydrofuran / 12 h / 45 °C

10: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; water; potassium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1,2-dichloro-benzene; toluene;

Reference yield:

: 749922-34-7
7-(benzyloxy)quinolin-4-ol

: 1394820-91-7
N-(3-fluoro-4-((7-((1-hydroxy-2-methylpropan-2-yl)oxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1: trichlorophosphate / toluene / 1 h / 120 °C

2: N-ethyl-N,N-diisopropylamine / toluene / 12 h / 115 °C

3: hydrogenchloride; water / 1,4-dioxane / 24 h / 100 °C

4: sodium hydroxide / 1 h / 20 °C

5: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 1 h / 20 °C

6: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / 0 °C

7: potassium formate / 5%-palladium/activated carbon / water; tetrahydrofuran / 12 h / 45 °C

8: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 4 h / Reflux

With hydrogenchloride; lithium aluminium tetrahydride; 1-hydroxy-7-aza-benzotriazole; water; potassium formate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; 5%-palladium/activated carbon; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;