N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

Base Information

Chemical Name:N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide
CAS No.:172900-95-7
Molecular Formula:C₃₁H₅₂N₂O₄
Molecular Weight:516.765
Hs Code.:

Synonyms:N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

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Chemical Property of N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

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Technology Process of N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

There total 7 articles about N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28384-61-4
methacrylic acid N-(butyl)amide

: 172900-84-4
2(S)-tert-butoxy-carbonyl-amino-4(S)-isopropyl-5-(p-tert-butyl-phenyl)-pentanal

: 173007-38-0
C₃₁H₅₂N₂O₄

: 172900-95-7
N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

Guidance literature:: methacrylic acid N-(butyl)amide; With n-butyllithium; In tetrahydrofuran; hexane; at -75 - 0 ℃; for 0.5h;

2(S)-tert-butoxy-carbonyl-amino-4(S)-isopropyl-5-(p-tert-butyl-phenyl)-pentanal; With triisopropoxytitanium(IV) chloride; In tetrahydrofuran; hexane; at -75 - 0 ℃; for 1.66667h;

Reference yield:

: 98-51-1
4-tert-butyltoluene

: 172900-95-7
N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

Guidance literature:: Multi-step reaction with 6 steps

1: NBS / CCl₄

2: 1.) LiHMDS, 2.) n-BuLi, LiAlH₄, BnSH / 1.) THF

3: NBS, PPh₃ / CH₂Cl₂

5: DIBAH / toluene

6: n-BuLi, TiCl(OiPr)3 / tetrahydrofuran

With triisopropoxytitanium(IV) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; diisobutylaluminium hydride; phenylmethanethiol; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; toluene;
DOI:10.1016/S0960-894X(97)10067-1

Reference yield:

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 172900-95-7
N-tert-butoxycarbonyl-2-methylene-4(S)-hydroxy-5(S)-amino-7(S)-isopropyl-8-(p-tert-butyl-phenyl)-octanoic acid (N-butyl) amide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LiHMDS, 2.) n-BuLi, LiAlH₄, BnSH / 1.) THF

2: NBS, PPh₃ / CH₂Cl₂

4: DIBAH / toluene

5: n-BuLi, TiCl(OiPr)3 / tetrahydrofuran

With triisopropoxytitanium(IV) chloride; N-Bromosuccinimide; lithium aluminium tetrahydride; n-butyllithium; diisobutylaluminium hydride; phenylmethanethiol; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/S0960-894X(97)10067-1