Lipase catalyzed aminolysis of ethyl propiolate and acrylic esters. Synthesis of chiral acrylamides

Article abstract of DOI:10.1016/S0040-4020(01)89914-2

Candida cylindracea lipase is a useful catalyst for the preparation of propiolamides. Candida antarctica lipase efficiently catalyzes the aminolysis of different acrylic esters and aliphatic amines; if racemic amines are used, the corresponding optically active acrylic amide is obtained in moderate-high enantiomeric excess.