N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

Base Information

Chemical Name:N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide
CAS No.:1374137-94-6
Molecular Formula:C₃₅H₃₇F₄N₅O₆S₂
Molecular Weight:763.834
Hs Code.:

N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

Synonyms:N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

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Chemical Property of N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

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Technology Process of N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

There total 5 articles about N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374138-34-7
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysine

: 1374137-94-6
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

Guidance literature:: With ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 ℃;

Reference yield:

: 1374138-31-4
methyl N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-5,5-difluoro-L-lysinate

: 1374137-94-6
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ammonium chloride; HATU / N,N-dimethyl-formamide / 0 °C

With pyridine; methanol; di-isopropyl azodicarboxylate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 181124-40-3
1,3-benzothiazole-6-sulfonyl chloride

: 1374137-94-6
N6-[N-(methoxycarbonyl)-β-phenyl-L-phenylalanyl]-N2-(1,3-benzothiazol-6-ylsulfonyl)-N2-[(3,3-difluorocyclobutyl)methyl]-5,5-difluoro-L-lysinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dmap / 85 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C

3.1: lithium hydroxide; methanol / tetrahydrofuran / 3 h / 0 - 20 °C

3.2: pH 4 / Sodium phosphate buffer

4.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; ammonium chloride; HATU / N,N-dimethyl-formamide / 0 °C

With pyridine; methanol; di-isopropyl azodicarboxylate; ammonium chloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; lithium hydroxide; dmap; In tetrahydrofuran; N,N-dimethyl-formamide;