2-Hexyne, 6-chloro-

Base Information

• Chemical Name: 2-Hexyne, 6-chloro-
• CAS No.: 28077-73-8
• Molecular Formula: C6H9 Cl
• Molecular Weight: 116.59
• Hs Code.: 2903299090
• Mol file: 28077-73-8.mol

Synonyms:1-Chloro-4-hexyne;6-Chloro-2-hexyne

Chemical Property of 2-Hexyne, 6-chloro-

Chemical Property:

• PSA: 0.00000
• LogP: 2.02870

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Hexyne, 6-chloro-

There total 5 articles about 2-Hexyne, 6-chloro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

1-chloro-4-pentyne (14267-92-6) + methyl iodide (74-88-4) → 6-chlorohex-2-yne (28077-73-8)

Guidance literature:

1-chloro-4-pentyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

methyl iodide; In tetrahydrofuran; hexane; at 20 ℃; for 1h;

DOI:10.1002/ejoc.201900701

Reference yield:

1-chloro-4-pentyne (14267-92-6) + methyl iodide (74-88-4) → 6-chlorohex-2-yne (28077-73-8) + 6-iodo-2-hexyne (28077-74-9)

Guidance literature:

1-chloro-4-pentyne; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 5h; Further stages.;

DOI:10.1039/b007324p

Reference yield:

1.3-chlorobromopropane (109-70-6) + prop-1-yne (74-99-7) → 6-chlorohex-2-yne (28077-73-8)

Guidance literature:

Multistep reaction; (i) Na, liq. NH₃, Fe(NO₃)3, (ii) /BRN= 605278/;

DOI:10.1021/ja00712a038

upstream raw materials:

1-chloro-4-pentyne

1.3-chlorobromopropane

prop-1-yne

methyl iodide

Downstream raw materials:

cis-1-chlorohex-4-ene

2-ethyl-1-pyrroline

6-iodo-2-hexyne

4-hexyn-1-ol

Refernces

• 1、 Watson,P.L.,Bergman,R.G.. "-". . p. 2055 - 2062. Retrieved 1979.
• 2、 Hodgson, David M.,Labande, Agnes H.,Pierard, Francoise Y. T. M.,Exposito Castro, Maria A.. "The scope of catalytic enantioselective tandem carbonyl ylide formation - Intramolecular [3 + 2] cycloadditions". . p. 6153 - 6159. Retrieved 2007/10/03.
• 3、 Li,Marks. "Organolanthanide-catalyzed intramolecular hydroamination/cyclization of aminoalkynes". . p. 9295 - 9306. Retrieved 2007/10/03.