isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

Base Information

Chemical Name:isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate
CAS No.:178610-76-9
Molecular Formula:C₂₃H₂₇NO₆
Molecular Weight:413.47
Hs Code.:

Synonyms:isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

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Chemical Property of isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

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Technology Process of isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

There total 4 articles about isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 75-30-9
2-iodo-propane

: 178610-75-8
4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyric acid

: 178610-76-9
isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 - 70 ℃; for 4h;
DOI:10.1021/jm010490l

Reference yield:

: 4-[2-(furan-2-yl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

: 178610-76-9
isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / NaH / dimethylformamide / 1 h / 0 - 20 °C

2: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

3: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

4: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

5: 95 percent / dimethylformamide / 2 h / 80 °C

6: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

7: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; sodium hydride; potassium carbonate; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Horner-Emmons reaction;
DOI:10.1021/jm010490l

Reference yield:

: 178610-70-3
ethyl (E)-4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxycinnamate

: 178610-76-9
isopropyl 4-[4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxyphenyl]butyrate

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / H₂ / 5percent Pd/C / ethyl acetate / atmospheric pressure

2: 83 percent / NaBH₄ / methanol; tetrahydrofuran / 3 h / Heating

3: 99 percent / Et₃N / ethyl acetate / 0.5 h / 0 - 20 °C

4: 95 percent / dimethylformamide / 2 h / 80 °C

5: 94 percent / 4N aq. KOH / 2-methoxy-ethanol / 2 h / Heating

6: 91 percent / K₂CO₃ / dimethylformamide / 4 h / 65 - 70 °C

With potassium hydroxide; sodium tetrahydroborate; hydrogen; potassium carbonate; triethylamine; 5percent Pd/C; In tetrahydrofuran; methanol; 2-methoxy-ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm010490l