methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

Base Information

Chemical Name:methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate
CAS No.:1417421-95-4
Molecular Formula:C₂₄H₂₅N₅O₄S
Molecular Weight:479.56
Hs Code.:

Synonyms:methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

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Chemical Property of methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

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Technology Process of methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

There total 6 articles about methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 866545-91-7
1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine

: 1417421-94-3
methyl 2-((2-chloropyrimidin-4-yl)amino)-2-methylbutanoate

: 1417421-95-4
methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

Guidance literature:: 1-(4-methylbenzenesulfonyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine; methyl 2-((2-chloropyrimidin-4-yl)amino)-2-methylbutanoate; With sodium carbonate; In 1,2-dimethoxyethane; for 0.5h; Inert atmosphere;

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; at 90 ℃; for 15h;

Reference yield:

: 882562-39-2
1-(4-methylbenzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-ylboronic acid

: 1417421-95-4
methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 1.08 h / 20 - 30 °C / Large scale

2.1: sodium carbonate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere

2.2: 15 h / 90 °C

With sodium carbonate; In 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 87162-70-7
methyl 2-amino-2-methylbutanoate

: 1417421-95-4
methyl 2-methyl-2-((2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)butanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / 1-methyl-pyrrolidin-2-one / 18 h / 80 °C

2.1: sodium carbonate / 1,2-dimethoxyethane / 0.5 h / Inert atmosphere

2.2: 15 h / 90 °C

With sodium carbonate; triethylamine; In 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane;