N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

Base Information

Chemical Name:N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide
CAS No.:1254312-98-5
Molecular Formula:C₃₀H₂₄F₉N₃O₃
Molecular Weight:645.524
Hs Code.:

Synonyms:N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

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Chemical Property of N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

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Technology Process of N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

There total 9 articles about N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1161274-19-6
4-cyano-2-methylbenzoyl chloride

: 1254318-25-6
3-amino-N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methylphenyl]-2-methoxy benzamide

: 1254312-98-5
N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

Guidance literature:: With pyridine; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 99548-55-7
4-bromo-2-methyl-benzoic acid methyl ester

: 1254312-98-5
N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C / Inert atmosphere

2: lithium hydroxide monohydrate / tetrahydrofuran; water / 3 h / 20 °C

3: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / 20 - 60 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; oxalyl dichloride; lithium hydroxide monohydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 573-54-6
2-bromo-3-nitro-benzoic acid

: 1254312-98-5
N-[2-ethyl-4-(1,2,2,3,3,3-hexafluoro-1-trifluoromethylpropyl)-6-methyl-phenyl]-3-(4-cyano-2-methylbenzoylamino)-2-methoxybenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / toluene / 1 h / 100 °C

2.1: pyridine / tetrahydrofuran / 18 h / 20 °C / Reflux

2.2: 41 h / 20 °C

3.1: potassium carbonate / 16 h / 20 °C

4.1: hydrogenchloride; tin(ll) chloride / water; isopropyl alcohol / 0 - 80 °C

4.2: pH 7 - 8

5.1: pyridine / tetrahydrofuran / 16 h / 20 °C

With pyridine; hydrogenchloride; thionyl chloride; potassium carbonate; tin(ll) chloride; N,N-dimethyl-formamide; In tetrahydrofuran; water; isopropyl alcohol; toluene;