4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

Base Information

Chemical Name:4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate
CAS No.:1616472-11-7
Molecular Formula:C₃₂H₄₁N₆O₉P
Molecular Weight:684.686
Hs Code.:

4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

Synonyms:4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

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Chemical Property of 4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

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Technology Process of 4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

There total 2 articles about 4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 7479-20-1
N-methyl-3-(indol-3-yl)propionic acid

: C₄₉H₅₁N₅O₁₀PPol

: 1616472-11-7
4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

Guidance literature:: C₄₉H₅₁N₅O₁₀PPol; With piperidine; benzotriazol-1-ol; In methanol; dichloromethane; N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

N-methyl-3-(indol-3-yl)propionic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

With chlorotriisopropylsilane; trifluoroacetic acid; In water; for 3h;
DOI:10.1016/j.bmcl.2014.04.114

Reference yield:

: 7479-20-1
N-methyl-3-(indol-3-yl)propionic acid

: Fmoc-Tyr(OPO(OBn)₂)-OH

: 132388-59-1
L-Asn(Trt)

: 162648-54-6
1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid

: 1616472-11-7
4-((S)-3-(1-((S)-1,4-diamino-1,4-dioxobutan-2-ylcarbamoyl)cyclohexylamino)-2-(3-(1-methyl-1H-indol-3-yl)propanamido)-3-oxopropyl)phenyldihydrogen phosphate

Guidance literature:: L-Asn(Trt); With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

With piperidine; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 0.333333h; Inert atmosphere;

N-methyl-3-(indol-3-yl)propionic acid; Fmoc-Tyr(OPO(OBn)₂)-OH; 1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid; Further stages;
DOI:10.1016/j.bmcl.2014.04.114