tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate
CAS No.:942142-78-1
Molecular Formula:C₁₉H₂₉ClN₂O₃
Molecular Weight:368.904
Hs Code.:

Synonyms:(R)-tert-butyl 3-((R)-(2-aminoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Suppliers and Price of tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate

Chemical Property:

Vapor Pressure:8.1E-09mmHg at 25°C

Purity/Quality:

Safty Information:

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Hazard Codes:

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Technology Process of tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate

There total 9 articles about tert-butyl (3R)-3-[(R)-2-aminoethoxy-(3-chlorophenyl)methyl]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-tert-butyl 3-((R)-(2-amino-2-oxoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

: 942142-78-1
(R)-tert-butyl 3-((R)-(2-aminoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at 0 - 20 ℃;

Reference yield:

: 942145-05-3
(R)-tert-butyl 3-((R)-(2-azidoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

: 942142-78-1
(R)-tert-butyl 3-((R)-(2-aminoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; under 760.051 Torr;
DOI:10.1016/j.bmcl.2009.11.066

Reference yield:

: 942142-76-9
(R)-tert-butyl 3-((R)-(3-chlorophenyl)(2-ethoxy-2-oxoethoxy)methyl)piperidine-1-carboxylate

: 942142-78-1
(R)-tert-butyl 3-((R)-(2-aminoethoxy)(3-chlorophenyl)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 20 °C

2: triethylamine / dichloromethane / 3 h / -5 - 20 °C

3: sodium azide / N,N-dimethyl-formamide / 16 h / 80 °C

4: water; triphenylphosphine / tetrahydrofuran / 16 h / 20 °C

With sodium tetrahydroborate; sodium azide; water; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml200137x