1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate
CAS No.:959999-74-7
Molecular Formula:C₁₈H₂₄ClNO₄
Molecular Weight:353.846
Hs Code.:

Synonyms:1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

Chemical Property:

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Technology Process of 1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 69240-96-6
1-(2-chloro-3-hydroxyphenyl)ethanone

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 959999-74-7
1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In diethyl ether; at 20 ℃; for 2.25h;

Reference yield: 70.0%

: 959999-74-7
1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

: 959999-73-6
1,1-dimethylethyl 4-({2-chloro-3-[(1S)-1-hydroxyethyl]phenyl}oxy)-1-piperidinecarboxylate

Guidance literature:: 1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate; With dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 20 ℃; for 20h;

With methanol; In tetrahydrofuran; toluene; at 20 ℃;

Reference yield:

: 959999-74-7
1,1-dimethylethyl 4-[(3-acetyl-2-chlorophenyl)oxy]-1-piperidinecarboxylate

: D-Methyl 5-(5-chloro-6-fluoro-1H-benzimidazol-1-yl)-3-({(1R)-1-[2-chloro-3-(4-piperidinyloxy)phenyl]ethyl}oxy)-2-thiophenecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran; toluene / 20 h

2: PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 1 h

With PS-triphenylphosphine; di-tert-butyl-diazodicarboxylate; dimethylsulfide borane complex; trifluoroacetic acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; toluene; 2: Mitsunobu reaction;