(S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Base Information

• Chemical Name: (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• CAS No.: 23037-82-3
• Molecular Formula: C9H15 N O3
• Molecular Weight: 185.2203
• Mol file: 23037-82-3.mol

Synonyms:Proline,1-acetyl-, ethyl ester, L- (8CI); 1-Acetyl-L-proline ethyl ester; Ethyl(S)-N-acetylprolinate; N-Acetylproline ethyl ester

Chemical Property of (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER

Chemical Property:

• PSA: 46.61000
• LogP: 0.49830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER

There total 7 articles about (S)-1-ACETYL-PYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethanol (64-17-5) + (S)-acetylproline (68-95-1) → (S)-ethyl 1-acetylpyrrolidine-2-carboxylate (23037-82-3)

Guidance literature:

With chloro-trimethyl-silane; at 20 ℃; for 21h;

DOI:10.3762/bjoc.13.241

Reference yield: 84.0%

Triethyl orthoacetate (78-39-7) + L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-ethyl 1-acetylpyrrolidine-2-carboxylate (23037-82-3)

Guidance literature:

In toluene; at 110 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.081

Reference yield: 50.0%

L-proline ethyl ester monohydrochloride (33305-75-8,131477-20-8) + acetyl chloride (75-36-5) → (S)-ethyl 1-acetylpyrrolidine-2-carboxylate (23037-82-3)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature; 1-2 h;

DOI:10.1016/S0040-4020(01)91595-9

upstream raw materials:

L-proline ethyl ester monohydrochloride

acetyl chloride

ethyl (2S)-pyrrolidine-2-carboxylate

L-proline

Downstream raw materials:

(S)-N-acetylpyrrolidinyl-1,1-dimethylmethanol

(S)-N-acetylpyrrolidinyl-1,1-diphenylmethanol

2-oxo-1-azabicyclo[3.3.0]oct-3-en-4-yl 2-nitrobenzoate

1-aza-3-(2-nitrobenzoyl)bicyclo[3.3.0]octane-2,4-dione