(1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol

Base Information

• Chemical Name: (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol
• CAS No.: 210993-14-9
• Molecular Formula: C₂₀H₂₈N₂O₂
• Molecular Weight: 328.455

Synonyms:(1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol

Chemical Property of (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol

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Technology Process of (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol

There total 4 articles about (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R,2S)-norephedrine (492-41-1,58550-13-3,757124-50-8) + ethylene dibromide (106-93-4) → (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol (210993-14-9)

Guidance literature:

(1R,2S)-norephedrine; ethylene dibromide; at 100 ℃; for 16h;

With sodium hydroxide; water; at 20 ℃;

DOI:10.1016/j.tetasy.2008.10.011

Reference yield: 60.0%

(1S,2R)-N,N'-bis-<(2-hydroxy-1-methyl-2-phenyl)ethyl>oxamide (151528-61-9) → (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol (210993-14-9)

Guidance literature:

With borane; In tetrahydrofuran; for 5h; Heating;

DOI:10.1016/S0957-4166(99)00049-X

Reference yield:

C26H40N2O2Si2 (1027270-14-9) → (1R,2S)-2-({2-[(1S,2R)-2-hydroxy-1-methyl-2-phenylethylamino]ethyl}amino)-1-phenylpropan-1-ol (210993-14-9)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 16h;

DOI:10.1248/cpb.54.1331

upstream raw materials:

(1S,2R)-N,N'-bis-<(2-hydroxy-1-methyl-2-phenyl)ethyl>oxamide

(1R,2S)-norephedrine

ethylene dibromide

C₂₆H₄₀N₂O₂Si₂

Downstream raw materials:

(4S,5R,2S,4'S,5'R,2'S)-N,N'-ethylene(4,4'-dimethyl-5,5'-diphenyl)-2,2'-bisoxazolidine

(5R,4S,2S,5'S,4'S,2'S)-N,N'-ethylene(5,5'-diphenyl-4,4',2,2'-tetramethyl)-2,2'-bisoxazolidine

(2R,4S,5R,17S,19S,20R)-N,N'-ethylene(2,4,19-trimethyl-5,17,20-triphenyl)-2,17-bisoxazolidine

1,4-bis<(1'S,2'R)-(2'-hydroxy-1'-methyl-2'-phenyl)>ethylpiperazine

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