ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

Base Information

Chemical Name:ethyl 2-(3-fluorophenyl)cyclopropane carboxylate
CAS No.:263893-75-0
Molecular Formula:C₁₂H₁₃FO₂
Molecular Weight:208.232
Hs Code.:

Synonyms:ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

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Chemical Property of ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

There total 1 articles about ethyl 2-(3-fluorophenyl)cyclopropane carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 623-73-4
diazoacetic acid ethyl ester

: 350-51-6
3-fluorostyrene

: 263893-75-0
ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

Guidance literature:

Reference yield:

: 263893-75-0
ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

: rac-trans-2-(3-fluorophenyl)-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With sodium methylate; In ethanol; for 40h; Reflux;
DOI:10.1016/j.bmc.2012.12.019

Reference yield:

: 263893-75-0
ethyl 2-(3-fluorophenyl)cyclopropane carboxylate

: 6-(((3R,4R)-4-(2-((1S,2R/1R,2S)-2-(3-fluorophenyl)cyclopropylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine trishydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium methylate / ethanol / 40 h / Reflux

2: lithium hydroxide; water / methanol / 16 h / 70 °C

3: diphenyl phosphoryl azide; triethylamine / 48 h / 85 °C

4: dichloromethane / 20 °C

5: sodium tris(acetoxy)borohydride; triethylamine / dichloromethane / 3 h / 20 °C

6: water; hydrogenchloride / methanol / 16 h / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; water; sodium methylate; sodium tris(acetoxy)borohydride; triethylamine; lithium hydroxide; In methanol; ethanol; dichloromethane; 3: |Curtius Rearrangement;
DOI:10.1016/j.bmc.2012.12.019