C₁₆H₂₂O₂

Base Information

• Chemical Name: C₁₆H₂₂O₂
• CAS No.: 1196708-17-4
• Molecular Formula: C₁₆H₂₂O₂
• Molecular Weight: 246.349
• Mol file: 1196708-17-4.mol

Synonyms:C₁₆H₂₂O₂

Chemical Property of C₁₆H₂₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₆H₂₂O₂

There total 4 articles about C₁₆H₂₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

Methyltriphenylphosphonium bromide (1779-49-3) + 3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde (176692-14-1) → C16H22O2 (1196708-17-4)

Guidance literature:

With sodium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 18h;

DOI:10.1016/j.tetlet.2009.08.092

Reference yield:

2-Iodobenzoic acid (88-67-5) → C16H22O2 (1196708-17-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: borane-THF / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2.1: pyridinium p-toluenesulfonate / acetone / Inert atmosphere

3.1: N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 22 h / 65 °C / Inert atmosphere

4.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

4.2: 2 h / 0 °C / Inert atmosphere

With borane-THF; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ja503322e

Reference yield:

2-iodobenzyl alcohol (5159-41-1) → C16H22O2 (1196708-17-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / acetone / Inert atmosphere

2.1: N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 22 h / 65 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 2 h / 0 °C / Inert atmosphere

With potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; palladium diacetate; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ja503322e

upstream raw materials:

Methyltriphenylphosphonium bromide

3-[2-(Tetrahydro-pyran-2-yloxymethyl)-phenyl]-propionaldehyde

2-Iodobenzoic acid

2-iodobenzyl alcohol

Downstream raw materials:

(2-(but-3-en-1-yl)phenyl)methanol