9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

Base Information

Chemical Name:9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine
CAS No.:663193-28-0
Molecular Formula:C₃₁H₄₀N₅O₇PS
Molecular Weight:657.728
Hs Code.:

Synonyms:9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

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Chemical Property of 9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

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Technology Process of 9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

There total 8 articles about 9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10310-21-1
2-Amino-6-chloropurin

: 663193-28-0
9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 8 h / 110 °C

2: 85 percent / NaH; 3-hydroxypropionitrile / tetrahydrofuran / 4 h / 20 °C

3: 68 percent / pyridine / 672 h / 50 °C

4: pyridine / 0.5 h

5: 1.90 g / S₈ / 1 h

With pyridine; sulfur; sodium hydride; potassium carbonate; 3-Hydroxypropionitrile; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b316304k

Reference yield:

: 27441-81-2
2,2-bis((benzyloxy)methyl)oxirane

: 663193-28-0
9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 5 steps

1: 67 percent / K₂CO₃ / dimethylformamide / 8 h / 110 °C

2: 85 percent / NaH; 3-hydroxypropionitrile / tetrahydrofuran / 4 h / 20 °C

3: 68 percent / pyridine / 672 h / 50 °C

4: pyridine / 0.5 h

5: 1.90 g / S₈ / 1 h

With pyridine; sulfur; sodium hydride; potassium carbonate; 3-Hydroxypropionitrile; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/b316304k

Reference yield:

: 663193-17-7
2-amino-9-[3-benzyloxy-2-(benzyloxymethyl)-2-hydroxypropyl]-6-chloropurine

: 663193-28-0
9-[3-benzyloxy-2-(benzyloxymethyl)-2-(diethoxythiophosphoryloxy)propyl]-N-2-isobutyrylguanine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / NaH; 3-hydroxypropionitrile / tetrahydrofuran / 4 h / 20 °C

2: 68 percent / pyridine / 672 h / 50 °C

3: pyridine / 0.5 h

4: 1.90 g / S₈ / 1 h

With pyridine; sulfur; sodium hydride; 3-Hydroxypropionitrile; In tetrahydrofuran;
DOI:10.1039/b316304k