4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene)

Base Information

• Chemical Name: 4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene)
• CAS No.: 441799-30-0
• Molecular Formula: C₁₈H₂₀Br₂O₃
• Molecular Weight: 444.163
• Mol file: 441799-30-0.mol

Synonyms:4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene)

Chemical Property of 4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene)

There total 1 articles about 4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-bromomethyl-4-bromobenzene (589-15-1) + diethylene glycol (111-46-6) → 4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene) (441799-30-0)

Guidance literature:

In tetrahydrofuran; Heating;

DOI:10.1021/jo0256181

Reference yield: 98.0%

4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene) (441799-30-0) + bis(pinacol)diborane (73183-34-3) → 2,2'-(4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(4,1-phenylene))bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane)

Guidance literature:

4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene); bis(pinacol)diborane; With potassium acetate; In 1,4-dioxane; for 1h; Inert atmosphere;

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 80 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1021/jacs.5b03551

Reference yield: 73.0%

4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene) (441799-30-0) + Triisopropyl borate (5419-55-6) → ((((oxybis(ethane-2,1-diyl))bis(oxy))bis(methylene))bis(4,1-phenylene))diboronic acid

Guidance literature:

4,4'-(2,2'-oxybis(ethane-2,1-diyl)bis(oxy))bis(methylene)bis(bromobenzene); With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; hexane; toluene; at -78 - -20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; toluene; at -20 - 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.8b03257

upstream raw materials:

1-bromomethyl-4-bromobenzene

diethylene glycol

Downstream raw materials:

C₂₀H₂₂O₅

1-(4-{2-[2-(4-propynoyl-benzyloxy)-ethoxy]-ethoxymethyl}-phenyl)-propynone