3-(Acetamidomethyl)pyridine

Base Information

• Chemical Name: 3-(Acetamidomethyl)pyridine
• CAS No.: 22977-34-0
• Molecular Formula: C8H10 N2 O
• Molecular Weight: 150.18
• Hs Code.: 2933399090
• European Community (EC) Number: 641-180-6
• DSSTox Substance ID: DTXSID10370625
• Nikkaji Number: J1.585.246A
• Wikidata: Q82157748
• Mol file: 22977-34-0.mol

Synonyms:3-(ACETAMIDOMETHYL)PYRIDINE;22977-34-0;N-(pyridin-3-ylmethyl)acetamide;N-(3-pyridinylmethyl)acetamide;Acetamide, N-(3-pyridinylmethyl)-;Maybridge1_000158;3-(Acetamidomethyl)pyridi;MixCom1_000312;Oprea1_654311;SCHEMBL45843;DTXSID10370625;KQZCRXVJXGYIFM-UHFFFAOYSA-N;N-(pyridin-3-yl methyl)acetamide;MFCD00495392;AKOS003869699;AS-80715;FT-0629666;E77577;A816453

Chemical Property of 3-(Acetamidomethyl)pyridine

Chemical Property:

• Vapor Pressure: 6.96E-06mmHg at 25°C
• Refractive Index: 1.523
• Boiling Point: 377°Cat760mmHg
• PKA: 15.21±0.46(Predicted)
• Flash Point: 181.8°C
• PSA: 41.99000
• Density: 1.088g/cm³
• LogP: 1.10860
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 150.079312947
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

97% ^*data from raw suppliers

3-(Acetamidomethyl)pyridine 95 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC1=CN=CC=C1

Technology Process of 3-(Acetamidomethyl)pyridine

There total 10 articles about 3-(Acetamidomethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Aminomethylpyridine (3731-52-0) + acetic anhydride (108-24-7) → N-(pyridin-3-ylmethyl)acetamide (22977-34-0)

Guidance literature:

In water; at 10 - 25 ℃; for 18h;

Reference yield: 90.0%

3-Aminomethylpyridine (3731-52-0) + ethyl acetate (141-78-6) → N-(pyridin-3-ylmethyl)acetamide (22977-34-0)

Guidance literature:

With acetic acid; at 80 ℃; for 20h; Sealed tube;

DOI:10.1039/c6cc09023k

Reference yield: 87.0%

3-Aminomethylpyridine (3731-52-0) + (1E)-3-acetyl-1,3-bis(2-chloro-4-nitrophenyl)-1-triazene → N-(pyridin-3-ylmethyl)acetamide (22977-34-0)

Guidance literature:

In acetonitrile; at 20 ℃; for 27h;

DOI:10.1016/S0040-4039(01)01358-2

upstream raw materials:

3-Aminomethylpyridine

acetic anhydride

nicotinaldehyde oxime

acetic acid

Downstream raw materials:

N-(1-benzylpiperidin-3-yl)methylacetamide

(±)-(1-benzylpiperidin-3-yl)methanamine

3-<(acetylamino)methyl>-1-benzyltetrahydropyridin-3-ene

N-(3-Pyridinylmethyl)-N-[[4-(tetradecyloxy)phenyl]methyl]acetamide