(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:1190082-07-5
Molecular Formula:C₂₀H₂₅NO₄
Molecular Weight:343.423
Hs Code.:

Synonyms:(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

There total 1 articles about (3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1190082-06-4
C₂₆H₃₁NO₄Se

: 1190082-07-5
(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With ozone;
DOI:10.1021/ol901704f

Reference yield: 93.0%

: 1190082-07-5
(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

: 1826-67-1
vinyl magnesium bromide

: 1190082-08-6
(3R,7R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-7-vinyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With copper(l) iodide; chloro-trimethyl-silane; lithium chloride;
DOI:10.1021/ol901704f

Reference yield: 80.0%

: 4264-35-1
2-acetylindole

: 1190082-07-5
(3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

: 1273047-26-9
(3R,7S,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-7-[2-(2-indolyl)-2-oxoethyl]-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5Hoxazolo[3,2-a]pyridine

: 1273048-03-5
(3R,6R,7R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-7-[2-(2-indolyl)-2-oxoethyl]-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5Hoxazolo[3,2-a]pyridine

Guidance literature:: (3R,8S,8aR)-6-(tert-butoxycarbonyl)-8-ethyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 1h;

2-acetylindole; In tetrahydrofuran; cyclohexane; at -78 - 20 ℃; for 4h; optical yield given as %de;
DOI:10.1002/ejoc.201001020