METHYL 2-AMINO-5-METHOXYBENZOATE

Base Information

• Chemical Name: METHYL 2-AMINO-5-METHOXYBENZOATE
• CAS No.: 2475-80-1
• Molecular Formula: C9H11 N O3
• Molecular Weight: 181.191
• Hs Code.: 2922509090
• Mol file: 2475-80-1.mol

Synonyms:m-Anisicacid, 6-amino-, methyl ester (7CI); 2-Amino-5-methoxybenzoic acid methyl ester;5-Methoxyanthranilic acid methyl ester; Methyl 2-amino-5-methoxybenzoate;Methyl 5-methoxy-2-aminobenzoate; Methyl 5-methoxyanthranilate; Methyl6-amino-m-anisate

Chemical Property of METHYL 2-AMINO-5-METHOXYBENZOATE

Chemical Property:

• Vapor Pressure: 0.00124mmHg at 25°C
• Melting Point: 37-38℃
• Refractive Index: 1.55
• Boiling Point: 298.8°C at 760 mmHg
• PKA: 2.70±0.10(Predicted)
• Flash Point: 145.2°C
• PSA: 61.55000
• Density: 1.179g/cm³
• LogP: 1.64520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly Soluble (1.1 g/L) (25°C) in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl2-Amino-5-methoxybenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Technology Process of METHYL 2-AMINO-5-METHOXYBENZOATE

There total 16 articles about METHYL 2-AMINO-5-METHOXYBENZOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 2-nitro-5-(methoxy)benzoate (2327-45-9) → methyl 2-amino-5-methoxybenzoate (2475-80-1)

Guidance literature:

With hydrogen; triethylamine; palladium hydroxide on carbon; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 70.1%

2-Amino-5-methoxybenzoic acid (6705-03-9) → methyl 2-amino-5-methoxybenzoate (2475-80-1)

Guidance literature:

With thionyl chloride; In methanol; for 3h; Reflux;

Reference yield: 56.0%

methanol (67-56-1) + 5-methoxyisatine (39755-95-8) → methyl 2-amino-5-methoxybenzoate (2475-80-1)

Guidance literature:

With tert.-butylhydroperoxide; caesium carbonate; at 20 - 30 ℃; for 4h; Sealed tube;

DOI:10.1016/j.tet.2019.01.067

upstream raw materials:

2-amino-5-hydroxybenzoic acid

methyl 2-amino-5-hydroxybenzoate

dimethyl sulfate

methyl 2-nitro-5-(methoxy)benzoate

Downstream raw materials:

2'-Carboxy-4'-methoxyoxanilic acid 1-ethyl 2'-methyl ester

methyl 2-acetylamino-5-methoxybenzoate

N-p-toluenesulfonyl-5-methoxyanthranilic acid methyl ester

6-methoxyquinazolin-4-ol

Refernces

• 1、 Wang, Yu-Wei,Zheng, Lei,Jia, Feng-Cheng,Chen, Yun-Feng,Wu, An-Xin. "Oxidative ring-opening of isatins for the synthesis of 2-aminobenzamides and 2-aminobenzoates". . p. 1497 - 1503. Retrieved 2019/02/13.
• 2、 -. "Preparation technology of 6-hydroxy-bentazone". Paragraph 0089; 0090; 0121; 0122; 0137; 0138. . Retrieved 2017/08/28.